Highly efficient catalysts derived from planar chiral ferrocenes for asymmetric transfer hydrogenation of ketones

✍ Scribed by Du Xiang-Dong; Dai Li-Xin; Hou Xue-Long; Xia Li-Jun; Tang Ming-Hua

• Publisher: John Wiley and Sons
• Year: 2010
• Tongue: English
• Weight: 207 KB
• Volume: 16
• Category: Article
• ISSN: 0256-7660
• DOI: 10.1002/cjoc.19980160113

✦ Synopsis

Planar chiral ferrocenes 1 and its diastereoisomer 2 were found to be good ligands for. the ruthenium catalyzed asymmetric transfer hydrogenation of ketones with i-PrOH as hydrogen source under refluxing in the presence of sodium hydroxide. The results showed that the absolute configuration of alcohol seemed to be governed by the central chirality in the oxazoline ring instead of the planar chirality. At a ratio of 1:2 for RuAigand, 3000:l S/C and >100,00O/h-' T O F were observed for acetophenone. For propiophenone 99% yield and 85% e.e. were obtained.

Keywords ruthenium complex

Asymmetric transfer hydrogenation, planar chiral phosphinoferrocenyloxazoline,