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Highly Efficient Approach to Orthogonally Protected (2 S ,4 R )- and (2 S ,4 S )-4-Hydroxyornithine

โœ Scribed by Paintner, Franz F.; Allmendinger, Lars; Bauschke, Gerd; Klemann, Patricia


Book ID
125898375
Publisher
American Chemical Society
Year
2005
Tongue
English
Weight
85 KB
Volume
7
Category
Article
ISSN
1523-7060

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A concise synthesis of protected (2S,4R)
โœ Satyendra Kumar Pandey; Menaka Pandey; Pradeep Kumar ๐Ÿ“‚ Article ๐Ÿ“… 2008 ๐Ÿ› Elsevier Science ๐ŸŒ French โš– 109 KB

A short synthesis of the nonproteinogenic amino acid, (2S,4R)-4-hydroxyornithine is described. Starting from racemic benzyl glycidol, the scaffold of the target compound was constructed in high enantio-and diastereoselectivity using Jacobsen's hydrolytic kinetic resolution (HKR) and regioselective o