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A concise synthesis of protected (2S,4R)-4-hydroxyornithine

✍ Scribed by Satyendra Kumar Pandey; Menaka Pandey; Pradeep Kumar

Publisher: Elsevier Science
Year: 2008
Tongue: French
Weight: 109 KB
Volume: 49
Category: Article
ISSN: 0040-4039
DOI: 10.1016/j.tetlet.2008.03.076

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✦ Synopsis

A short synthesis of the nonproteinogenic amino acid, (2S,4R)-4-hydroxyornithine is described. Starting from racemic benzyl glycidol, the scaffold of the target compound was constructed in high enantio-and diastereoselectivity using Jacobsen's hydrolytic kinetic resolution (HKR) and regioselective opening of an epoxide as key steps.

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