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Synthesis of orthogonally protected (3R,4S)- and (3S,4S)-4,5-diamino-3-hydroxypentanoic acids

✍ Scribed by Z. Czajgucki; P. Sowiński; R. Andruszkiewicz


Publisher
Springer
Year
2003
Tongue
English
Weight
171 KB
Volume
24
Category
Article
ISSN
0939-4451

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Stereoselective synthesis of (2S,3S,4R,5
✍ Makoto Oba; Tsutomu Terauchi; Jun Hashimoto; Tomohiro Tanaka; Kozaburo Nishiyama 📂 Article 📅 1997 🏛 Elsevier Science 🌐 French ⚖ 227 KB

A catalytic deuteration of protected 3,4-dehydro-L-proline using RuCI2(PPh3) 3 followed by RuO~-oxidation gave a 3,4-dideuterated L-pyroglutamic acid derivative which is considered to be a promising precursor for various deuterated amino acids. The present study demonstrates a stereoselective reduct