## Abstract An efficient highly diastereoselective synthesis of quaternary α‐trifluoromethyl amino acids (III) and (V) is developed via allylation of enantiopure imines of trifluoropyruvate (I).
✦ LIBER ✦
Highly diastereoselective synthesis of quaternary α-trifluoromethyl α-amino acids from chiral imines of trifluoropyruvate
✍ Scribed by Min, Qiao-Qiao; He, Chun-Yang; Zhou, Haibing; Zhang, Xingang
- Book ID
- 111857955
- Publisher
- Royal Society of Chemistry
- Year
- 2010
- Tongue
- English
- Weight
- 640 KB
- Volume
- 46
- Category
- Article
- ISSN
- 1359-7345
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A new and prepamtively useful method for the synthesis of non racemic ct.trifluoromethyl ('grin) or-amino acids (AAs) is presented. Kcy-lmilding blocks are the sulfinirqines (S)-la,b, prepared via Sta, u41ng¢lreaction from triflu~c (mttt's and the chiral N-sulfinyl iminophosphorane (S)-5, which were