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Highly diastereoselective synthesis of quaternary α-trifluoromethyl α-amino acids by addition of benzylzinc reagents to chiral imines of trifluoropyruvate

✍ Scribed by Jie Yang; Qiao-Qiao Min; Yi He; Xingang Zhang


Book ID
113929712
Publisher
Elsevier Science
Year
2011
Tongue
French
Weight
536 KB
Volume
52
Category
Article
ISSN
0040-4039

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## Abstract An efficient highly diastereoselective synthesis of quaternary α‐trifluoromethyl amino acids (III) and (V) is developed via allylation of enantiopure imines of trifluoropyruvate (I).