Autophagy, a tightly regulated homeostatic pro-survival mechanism, has also been implicated in pathogen recognition and clearance by macrophages as part of the innate immune response. In the May issue of EJI, Mitroulis et al. shed light into the role of autophagy in human neutrophil biology, associa
Highlights from other journals
- Publisher
- John Wiley and Sons
- Year
- 2010
- Tongue
- English
- Weight
- 121 KB
- Volume
- 33
- Category
- Article
- ISSN
- 0265-9247
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โฆ Synopsis
To gain a deeper understanding of evolutionary genetic history and an appreciation of conserved genomic regions of functional significance, Zhang et al. report a comparative analysis of human genome sequence with those of the chimpanzee and the recently sequenced Neanderthal. They identify pathogenic variants in humans that may represent ''compensated'' wild-type alleles in at least one of these two closely related species. By performing a ''triangulation'' of all three genome sequences, they identified over hundred pathogenic and regulatory genetic changes that
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