Autophagy, a tightly regulated homeostatic pro-survival mechanism, has also been implicated in pathogen recognition and clearance by macrophages as part of the innate immune response. In the May issue of EJI, Mitroulis et al. shed light into the role of autophagy in human neutrophil biology, associa
Highlights from other journals
- Publisher
- John Wiley and Sons
- Year
- 2010
- Tongue
- English
- Weight
- 166 KB
- Volume
- 32
- Category
- Article
- ISSN
- 0265-9247
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โฆ Synopsis
A chronic immune response usually ends up producing collateral damage to the body as well as attacking the pathogen, but regulatory T cells (Treg) limit such damage. Acute infections can produce very vigorous immune reactions that are also capable of producing significant collateral damage, so does the same mechanism exist there? Yes, according to Piersma et al., who show that pathogen-specific Treg are induced in acute viral infections in healthy humans. IL-10 is essential in limiting collateral damage during an immune
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