๐”– Bobbio Scriptorium
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Highlights from other journals

Publisher
John Wiley and Sons
Year
2010
Tongue
English
Weight
127 KB
Volume
32
Category
Article
ISSN
0265-9247

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โœฆ Synopsis

The methylotrophic yeast Pichia pastoris has become a platform for producing heterologous recombinant proteins of pharmaceutical importance, thanks to its ability to reproduce posttranslational modifications similar to those of higher eukaryotes. The groups of Sang Yup Lee and Diethard Mattanovich present the first reconstruction of a genome-scale metabolic model of the P. pastoris type strain DSMZ 70382, PpaMBEL1254. It consists of 1,254 metabolic reactions and 1,147 metabolites compartmentalised into eight different regions, representing organelles. The researchers incorporated equations describing the production of two heterologous proteins, human serum albumin and human superoxide dismutase, and analysed the impact of oxygen limitation on protein production. -us

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