High yield acyl anion trapping reactions: direct nucleophilic acylation of isocyanates and isothiocyanates.
✍ Scribed by Dietmar Seyferth; Richard C. Hui
- Publisher
- Elsevier Science
- Year
- 1984
- Tongue
- French
- Weight
- 235 KB
- Volume
- 25
- Category
- Article
- ISSN
- 0040-4039
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## Abstract Various 4‐substituted benzo[__c__][2,7]naphthyridines were prepared from the corresponding 4‐chloro derivative by Pd(0) coupling reaction or nucleophilic substitution. More particularly, 4‐aroyl‐benzo[e][2,7]naph‐thyridines were synthesized by aroylation with arenecarbaldehydes in the p
The magnitude of the a-effect for reactions of 4-nitrophenyl substituted benzoates with a pair of anionic nucleophiles is independent of the electronic nature of the acyl substituent, while the one for the corresponding reactions with a pair of neutral nucleophiles increases as the acyl substituent