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Reaction of 1,2,4-triazines with nitronate anions, direct nucleophilic acylation of 1,2,4-triazines.
✍ Scribed by A. Rykowski; M. M̨akosza
- Publisher
- Elsevier Science
- Year
- 1984
- Tongue
- French
- Weight
- 126 KB
- Volume
- 25
- Category
- Article
- ISSN
- 0040-4039
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📜 SIMILAR VOLUMES
## Abstract magnified image A simple and high yielding preparation of pyrazolo[4,3‐__e__][1,2,4]triazines and 4‐cyano‐3‐methyl‐1‐phenylpyrazole derivatives from corresponding phenylhydrazones of 5‐acyl‐1,2,4‐triazines by melt under acidic medium and by thermal heating, respectively.
To develop nonacidic, nonsteroidal anti-inflammatory agents without GI complications, a series of asymmetric triazines was synthesized and evaluated for anti-inflammatory efficacy in the carrageenan-induced pedal edema assay. Toxicity was estimated by determination of approximate LD50 values in mice