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Transformations of phenylhydrazones of 5-acyl-1,2,4-triazines to pyrazolo[4,3-e][1,2,4]triazines or 4-cyanopyrazole

โœ Scribed by Mariusz Mojzych; Andrzej Rykowski


Publisher
Journal of Heterocyclic Chemistry
Year
2007
Tongue
English
Weight
310 KB
Volume
44
Category
Article
ISSN
0022-152X

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โœฆ Synopsis


Abstract

magnified image

A simple and high yielding preparation of pyrazolo[4,3โ€e][1,2,4]triazines and 4โ€cyanoโ€3โ€methylโ€1โ€phenylpyrazole derivatives from corresponding phenylhydrazones of 5โ€acylโ€1,2,4โ€triazines by melt under acidic medium and by thermal heating, respectively.


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## Abstract Acid hydrolysis of 2,4,6โ€Tris(aminoalkenyl)โ€1,3,5โ€triazines 1 gives 4โ€aminoโ€5โ€arylโ€2โ€benzylpyrimidines 3 by ring transformation including elimination of amine, formic acid, and carboxylic acid.