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Ring Transformation of 2,4,6-Tris(aminoalkenyl)-1,3,5-triazines to 4-Aminopyrimidines

✍ Scribed by Schulz, Hans-Joachim ;Liebscher, Jürgen ;Maas, Gerhard


Publisher
John Wiley and Sons
Year
1992
Tongue
English
Weight
184 KB
Volume
1992
Category
Article
ISSN
0947-3440

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✦ Synopsis


Abstract

Acid hydrolysis of 2,4,6‐Tris(aminoalkenyl)‐1,3,5‐triazines 1 gives 4‐amino‐5‐aryl‐2‐benzylpyrimidines 3 by ring transformation including elimination of amine, formic acid, and carboxylic acid.


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## Abstract magnified image A simple and high yielding preparation of pyrazolo[4,3‐__e__][1,2,4]triazines and 4‐cyano‐3‐methyl‐1‐phenylpyrazole derivatives from corresponding phenylhydrazones of 5‐acyl‐1,2,4‐triazines by melt under acidic medium and by thermal heating, respectively.