Reactivity of 4-chlorobenzo[c][2,7]naphthyridines towards Pd(0) catalyzed coupling reactions and nucleophilic substitutions. aroylation by nucleophilic substitution with analogues of acyl anions

✍ Scribed by G. Duvey; F. Nivoliers; P. Rocca; A. Godard; F. Marsais; G. Quéguiner

• Publisher: Journal of Heterocyclic Chemistry
• Year: 2001
• Tongue: English
• Weight: 74 KB
• Volume: 38
• Category: Article
• ISSN: 0022-152X
• DOI: 10.1002/jhet.5570380505

✦ Synopsis

Abstract

Various 4‐substituted benzo[c][2,7]naphthyridines were prepared from the corresponding 4‐chloro derivative by Pd(0) coupling reaction or nucleophilic substitution. More particularly, 4‐aroyl‐benzo[e][2,7]naph‐thyridines were synthesized by aroylation with arenecarbaldehydes in the presence of 1,3‐dimethylimida‐zolium iodide.