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High-Resolution Integrated Map Encompassing the Breast Cancer Loss of Heterozygosity Region on Human Chromosome 16q22.1

✍ Scribed by Eirik Frengen; Philippe Rocca-Serra; Sergey Shaposhnikov; Laurence Taine; Jim Thorsen; Christophe Bepoldin; Martin Krekling; Delfine Lafon; Kaja Klykken Aas; Azza Abd El Monéim; Henning Johansen; Michel Longy; Hans Prydz; Françoise Dorion-Bonnet


Book ID
115615303
Publisher
Elsevier Science
Year
2000
Tongue
English
Weight
729 KB
Volume
70
Category
Article
ISSN
0888-7543

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The analysis of loss of heterozygosity (LOH) in tumours can be a powerful tool for mapping the sites of tumour suppressor genes in the human genome. A panel of breast cancer patients was assembled as pairs of tumour and lymphocyte DNA samples and LOH studies carried out by Southern hybridisation wit