𝔖 Bobbio Scriptorium
✦   LIBER   ✦

High magnetic field water and metabolite proton T1 and T2 relaxation in rat brain in vivo

✍ Scribed by Robin A. de Graaf; Peter B. Brown; Scott McIntyre; Terence W. Nixon; Kevin L. Behar; Douglas L. Rothman

Publisher
John Wiley and Sons
Year
2006
Tongue
English
Weight
612 KB
Volume
56
Category
Article
ISSN
0740-3194

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

Comprehensive and quantitative measurements of T~1~ and T~2~ relaxation times of water, metabolites, and macromolecules in rat brain under similar experimental conditions at three high magnetic field strengths (4.0 T, 9.4 T, and 11.7 T) are presented. Water relaxation showed a highly significant increase (T~1~) and decrease (T~2~) with increasing field strength for all nine analyzed brain structures. Similar but less pronounced effects were observed for all metabolites. Macromolecules displayed field‐independent T~2~ relaxation and a strong increase of T~1~ with field strength. Among other features, these data show that while spectral resolution continues to increase with field strength, the absolute signal‐to‐noise ratio (SNR) in T~1~/T~2~‐based anatomical MRI quickly levels off beyond ∼7 T and may actually decrease at higher magnetic fields. Magn Reson Med, 2006. © 2006 Wiley‐Liss, Inc.

📜 SIMILAR VOLUMES

T1 relaxation in in vivo mouse brain at
T1 relaxation in in vivo mouse brain at ultra-high field
✍ Rob C.G. van de Ven; Bianca Hogers; Arn M.J.M. van den Maagdenberg; Huub J.M. de 📂 Article 📅 2007 🏛 John Wiley and Sons 🌐 English ⚖ 243 KB

## Abstract Accurate knowledge of relaxation times is imperative for adjustment of MRI parameters to obtain optimal signal‐to‐noise ratio (SNR) and contrast. As small animal MRI studies are extended to increasingly higher magnetic fields, these parameters must be assessed anew. The goal of this stu

Proton T2 relaxation of cerebral metabol
Proton T2 relaxation of cerebral metabolites during transient global ischemia in rat brain
✍ Hiroyuki Fujimori; Thomas Michaelis; Markus Wick; Jens Frahm 📂 Article 📅 1998 🏛 John Wiley and Sons 🌐 English ⚖ 382 KB

Putative changes of metabolite T2 relaxation times were investigated before and after a 20-min period of global ischemia in rat brain in vivo (n = 10) using localized proton MRS at different echo times (2.35 T). Neither absolute T2 relaxation times (TE = 20-270 ms) nor time courses of T2-weighted me

In vivo31P nuclear magnetic resonance st
In vivo31P nuclear magnetic resonance studies of T1 and T2 relaxation times in rat brain and in rat brain tumors implanted to nude mice
✍ C. Remy; J. P. Albrand; A. L. Benabid; M. Decorps; M. Jacrot; J. Riondel; M. F. 📂 Article 📅 1987 🏛 John Wiley and Sons 🌐 English ⚖ 492 KB

IP NMR spin-lattice (TI) and spin-spin (T2) relaxation times of phosphocreatine, ATP, inorganic phosphate, and phosphomonoesters have been measured in vivo at 4.1 T in rat brain and rat brain tumors implanted on nude mice. The relaxation data were acquired using a phase-cycled saturation-recovery sp

Comparison of T1 and T2 metabolite relax
Comparison of T1 and T2 metabolite relaxation times in glioma and normal brain at 3T
✍ Yan Li; Radhika Srinivasan; Helene Ratiney; Ying Lu; Susan M. Chang; Sarah J. Ne 📂 Article 📅 2008 🏛 John Wiley and Sons 🌐 English ⚖ 549 KB

## Abstract ## Purpose To measure T~1~ and T~2~ relaxation times of metabolites in glioma patients at 3T and to investigate how these values influence the observed metabolite levels. ## Materials and Methods A total of 23 patients with gliomas and 10 volunteers were studied with single‐voxel two