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Proton T2 relaxation of cerebral metabolites during transient global ischemia in rat brain

✍ Scribed by Hiroyuki Fujimori; Thomas Michaelis; Markus Wick; Jens Frahm

Publisher
John Wiley and Sons
Year
1998
Tongue
English
Weight
382 KB
Volume
39
Category
Article
ISSN
0740-3194

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✦ Synopsis

Putative changes of metabolite T2 relaxation times were investigated before and after a 20-min period of global ischemia in rat brain in vivo (n = 10) using localized proton MRS at different echo times (2.35 T). Neither absolute T2 relaxation times (TE = 20-270 ms) nor time courses of T2-weighted metabolite signals (TE = 135 ms) revealed statistically significant changes during the occlusion or early reperfusion relative to pre-ischemic baseline. These findings are in line with reports of relaxation changes at much later stages and further demonstrate that altered T2 relaxation is not a confounding factor in diffusion-weighted long-TE proton MRS during early ischemic events.

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