High-dose cytosine arabinoside intensification for acute nonlymphocytic leukemia in patients over 56 years of age
✍ Scribed by A. Ferrant; C. Doyen; A. Delannoy; L. Van den Bossche; P. Martiat; V. Deneys; M. De Bruyère; A. Bosly; J. L. Michaux; G. Sokal
- Publisher
- Springer
- Year
- 1992
- Tongue
- English
- Weight
- 526 KB
- Volume
- 64
- Category
- Article
- ISSN
- 0939-5555
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Effective treatment of the elderly patients (265 years) with acute nonlymphocytic leukemia (ANLL) remains elusive and controversial. In the present study, single-agent Cytosine Arabinoside (AM-C) was administered at an intermediate dose level (500 mg/m2 intravenously [I.V.] I-hour infusion q12 hours
High-dose cytosine arabinoside (Ara-C) was used in adult patients with refractory acute nonlymphoblastic leukemia, either alone (3 g/m2 every 12 h X 12 doses) or with 3 additional days of anthracycline antibiotics. The systemic toxicities were similar for both groups without an increase in the group