Effective treatment of the elderly patients (265 years) with acute nonlymphocytic leukemia (ANLL) remains elusive and controversial. In the present study, single-agent Cytosine Arabinoside (AM-C) was administered at an intermediate dose level (500 mg/m2 intravenously [I.V.] I-hour infusion q12 hours
The role of timing of high-dose cytosine arabinoside intensification and of maintenance therapy in the treatment of children with acute nonlymphocytic leukemia
β Scribed by William G. Woods; Frederick B. Ruymann; Beatrice C. Lampkin; Jonathan D. Buckley; Irwin D. Bernstein; Ashok K. Srivastava; W. Anthony Smithson; Denis R. Benjamin; Stephen A. Feig; Tae H. Kim; Lorrie F. Odom; Robert J. Wells; G. Denman Hammond
- Publisher
- John Wiley and Sons
- Year
- 1990
- Tongue
- English
- Weight
- 809 KB
- Volume
- 66
- Category
- Article
- ISSN
- 0008-543X
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Twenty-five adult patients with refractory acute lymphocytic leukemia received salvage therapy with mitoxantrone 5 mg/m2 intravenously over 1 hour daily for 5 days and cytosine arabinoside 3 g/m2 intravenously over 2 hours every 12 hours for six doses. Overall, nine patients (36%) achieved complete