High-dose cytosine arabinoside in the treatment of acute myeloid leukemia : Review of three randomized trials
โ Scribed by Wolfgang Kern; Elihu H. Estey
- Publisher
- John Wiley and Sons
- Year
- 2006
- Tongue
- English
- Weight
- 400 KB
- Volume
- 107
- Category
- Article
- ISSN
- 0008-543X
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๐ SIMILAR VOLUMES
Effective treatment of the elderly patients (265 years) with acute nonlymphocytic leukemia (ANLL) remains elusive and controversial. In the present study, single-agent Cytosine Arabinoside (AM-C) was administered at an intermediate dose level (500 mg/m2 intravenously [I.V.] I-hour infusion q12 hours
Twenty-five adult patients with refractory acute lymphocytic leukemia received salvage therapy with mitoxantrone 5 mg/m2 intravenously over 1 hour daily for 5 days and cytosine arabinoside 3 g/m2 intravenously over 2 hours every 12 hours for six doses. Overall, nine patients (36%) achieved complete
High doses of Cytosine-arabinoside (Ara-C) (1 to 3gm/mz every 12 hours during 48 hours) were administered monthly to 5 acute myeloid leukemia patinets during complete remissions subsequent to relapses and reinduction treatment. Plasma Ara-C was measured using a radioimmunoassay and exhibited kinetic