High doses of cytosine arabinoside (HD-Ara-C) as reinforcement during remission of acute myeloid leukemia

✍ Scribed by Zittoun, R. ;Marie, J. P. ;Pommier, Y. ;Pochat, L.

• Publisher: John Wiley and Sons
• Year: 1982
• Tongue: English
• Weight: 153 KB
• Volume: 10
• Category: Article
• ISSN: 0098-1532
• DOI: 10.1002/mpo.2950100727

✦ Synopsis

High doses of Cytosine-arabinoside (Ara-C) (1 to 3gm/mz every 12 hours during 48 hours) were administered monthly to 5 acute myeloid leukemia patinets during complete remissions subsequent to relapses and reinduction treatment. Plasma Ara-C was measured using a radioimmunoassay and exhibited kinetics compatible with a bi-or tri-compartimental model. Tolerance was good, with mainly gastrointestinal toxicity and somnolence. The duration of remissions was relatively long, taking into account that these were second or third remissions.