High doses of Cytosine-arabinoside (Ara-C) (1 to 3gm/mz every 12 hours during 48 hours) were administered monthly to 5 acute myeloid leukemia patinets during complete remissions subsequent to relapses and reinduction treatment. Plasma Ara-C was measured using a radioimmunoassay and exhibited kinetic
Clinical results and pharmacokinetics of high-dose cytosine arabinoside (HD ARA-C)
✍ Scribed by Doz. Dr. Henning Breithaupt; Hans Pralle; Thomas Eckhardt; Michael Von Hattingberg; Jürgen Schick; Helmut Löffler
- Publisher
- John Wiley and Sons
- Year
- 1982
- Tongue
- English
- Weight
- 714 KB
- Volume
- 50
- Category
- Article
- ISSN
- 0008-543X
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High-dose cytosine arabinoside (Ara-C) was used in adult patients with refractory acute nonlymphoblastic leukemia, either alone (3 g/m2 every 12 h X 12 doses) or with 3 additional days of anthracycline antibiotics. The systemic toxicities were similar for both groups without an increase in the group