Eighteen children with acute myeloid leukemia have been treated with a fourdrug protocol using cytosine arabinoside, daunorubicin, prednisolone, and mercaptopurine or thioguanine. The initial remission rate overall was 78%. Of 15 children who completed a week's treatment, i.e. one complete cycle, 14
Treatment of acute myeloid leukemia of adults with cytosine arabinoside in combination with 6-mercaptopurine
β Scribed by John G. Buchanan; John R. D. Matthews; J. Graham Davison; Robert R. Grigor; Thomas P. Casey
- Publisher
- John Wiley and Sons
- Year
- 1973
- Tongue
- English
- Weight
- 576 KB
- Volume
- 32
- Category
- Article
- ISSN
- 0008-543X
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## Abstract The combination of arabinosyl cytosine and 6βthioguanine has been effective for the treatment of acute leukemia. Three schedules of this combination were studied to determine which was most effective, especially in patients who had prior exposure to either or both of these drugs. Sequen
A randomized study of methotrexate vs. 6-mercaptopurine and prednisone was carried out in 45 previously untreated patients with acute leukemia. Methotrexate was given orally in divided daily doses for 5-day courses a t intervals of ten to 14 days. Six-mercaptopurine and prednisone were given daily u