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Heterocycles from substituted amides. IX. 4,5-dihydro-1,2,4-triazin-6-(1H)ones from 2-isocyanoacetates and hydrazine

✍ Scribed by Kindrick L. Leschinsky; John P. Chupp


Book ID
112126233
Publisher
Journal of Heterocyclic Chemistry
Year
1980
Tongue
English
Weight
131 KB
Volume
17
Category
Article
ISSN
0022-152X

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Efficient solid-phase synthesis of 4,5-d
✍ Damien Boeglin; Sonia Cantel; Jean Martinez; Jean-Alain Fehrentz πŸ“‚ Article πŸ“… 2003 πŸ› Elsevier Science 🌐 French βš– 121 KB

A new and easy protocol for the formation of substituted 4,5-dihydro-1,2,4-triazin-6(1H)-ones was developed on solid support. The heterocyclic compounds were formed by nucleophilic reaction of hydrazine on thioamide esters. As cyclization was concomitant with cleavage from the support, substituted 4