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Hepatotoxicity of 1-(2-chloroethyl)-3-cyclohexyl-1-nitrosourea (CCNU) in dogs: The use of serial percutaneous liver biopsies

โœ Scribed by M.C. Henry; R.D. Davis; P.S. Schein

Book ID
119001808
Publisher
Elsevier Science
Year
1973
Tongue
English
Weight
648 KB
Volume
25
Category
Article
ISSN
0041-008X

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Physiologic disposition of 1-(2-chloroethyl)-3-cyclohexyl-1-nitrosourea (CCNU) and 1-(2-chloroethyl)-3-(4-methyl cyclohexyl)-1-nitrosourea (MeCCNU) in man
โœ Robert W. Sponzo; Vincent T. Devita; Vincent T. Oliverio ๐Ÿ“‚ Article ๐Ÿ“… 1973 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 466 KB ๐Ÿ‘ 2 views

The physiologic disposition of radioactive-labelled CCNU and MeCCNU was studied in patients receiving these drugs as part of their early clinical trial. CCNU was given orally in doses of 30-100 mg/m2 a n d MeCCNU in doses of 120-290 mg/m?. With both drugs, significant plasma levels of radioactivity