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CCNU (1-[2-chloroethyl]-3-cyclohexyl-1-nitrosourea, NSC-79037) in the treatment of cancer. Phase II study

โœ Scribed by Barth Hoogstraten; Jeffrey A. Gottlieb; Eulogio Caoili; William G. Tucker; Robert W. Talley; Arthur Haut

Publisher
John Wiley and Sons
Year
1973
Tongue
English
Weight
458 KB
Volume
32
Category
Article
ISSN
0008-543X

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Forward mutations induced by 1-(2-chloroethyl)-3-cyclohexyl-1-nitrosourea (CCNU) in the supF gene of Escherichia coli were recovered from bacteria deficient in nucleotide excision repair and in DNA-alkyltransferase activity. Bacteria were exposed to 0.4 mM CCNU (in vivo supF mutagenesis), increasing