Amphotericin B plus 1,3-BIS (2-chloroethyl)-1-nitrosourea (BCNU-NSC NO. 409962) in advanced cancer. Phase I and preliminary phase II results

Phase II study of 1,3-Bis (2-chloroethyl

Phase II study of 1,3-Bis (2-chloroethyl)-1-nitrosourea (BCNU, NSC #409962) with amphotericin B in bronchogenic carcinoma

✍ Cary A. Presant; Stephen Hillinger; Carol Klahr 📂 Article 📅 1980 🏛 John Wiley and Sons 🌐 English ⚖ 466 KB

Eighteen patients with unresectable bronchogenic carcinoma were treated with amphotericin B (7.5 mgim' on day I , I5 mg/m2 on day 2, and 30 mg/m2 on days 3 and 4) plus BCNU (250 mg/m2 on day 4 following amphotericin B) with courses of therapy repeated every 8 weeks. All patients had metastatic disea