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Adriamycin and 1-(2-Chlorethyl)-3-Cyclohexyl-1-Nitrosourea (CCNU) in the treatment of metastatic breast cancer

โœ Scribed by William C. Waterfield; Charles K. Tashima; Gabriel N. Hortobagyi; George R. Blumenschein; Aman U. Buzdar; Michael A. Burgess

Publisher
John Wiley and Sons
Year
1978
Tongue
English
Weight
354 KB
Volume
41
Category
Article
ISSN
0008-543X

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Forward mutations induced by 1-(2-chloroethyl)-3-cyclohexyl-1-nitrosourea (CCNU) in the supF gene of Escherichia coli were recovered from bacteria deficient in nucleotide excision repair and in DNA-alkyltransferase activity. Bacteria were exposed to 0.4 mM CCNU (in vivo supF mutagenesis), increasing