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A toxicologic comparison of the potency and activity of 1,3-bis(2-chloroethyl)-1-nitrosourea (BCNU) and 1-(2-chloroethyl)-3-cyclohexyl-1-nitrosourea (CCNU) in mice and rats

✍ Scribed by George R. Thompson; Robert E. Larson


Book ID
119001561
Publisher
Elsevier Science
Year
1972
Tongue
English
Weight
640 KB
Volume
21
Category
Article
ISSN
0041-008X

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Physiologic disposition of 1-(2-chloroet
✍ Robert W. Sponzo; Vincent T. Devita; Vincent T. Oliverio πŸ“‚ Article πŸ“… 1973 πŸ› John Wiley and Sons 🌐 English βš– 466 KB πŸ‘ 2 views

The physiologic disposition of radioactive-labelled CCNU and MeCCNU was studied in patients receiving these drugs as part of their early clinical trial. CCNU was given orally in doses of 30-100 mg/m2 a n d MeCCNU in doses of 120-290 mg/m?. With both drugs, significant plasma levels of radioactivity