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Relationship of 1,3-bis(2-chloroethyl)-1-nitrosourea (BCNU) and 1-(2-chloroethyl)-3-cyclohexyl-1-nitrosourea (CCNU) pharmacokinetics of uptake, distribution, and tissue/plasma partitioning in rat organs and intracerebral tumors

✍ Scribed by V. A. Levin; P. A. Kabra; M. A. Freeman-Dove

Book ID
112286056
Publisher
Springer
Year
1978
Tongue
English
Weight
828 KB
Volume
1
Category
Article
ISSN
0344-5704

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✍ Robert W. Sponzo; Vincent T. Devita; Vincent T. Oliverio πŸ“‚ Article πŸ“… 1973 πŸ› John Wiley and Sons 🌐 English βš– 466 KB πŸ‘ 2 views

The physiologic disposition of radioactive-labelled CCNU and MeCCNU was studied in patients receiving these drugs as part of their early clinical trial. CCNU was given orally in doses of 30-100 mg/m2 a n d MeCCNU in doses of 120-290 mg/m?. With both drugs, significant plasma levels of radioactivity