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Hydroxylation of the carcinostatic 1-(2-chloroethyl)-3-cyclohexyl-1-nitrosourea (CCNU) by rat liver microsomes

โœ Scribed by Hubert E. May; Richard Boose; Donald J. Reed

Book ID
118309700
Publisher
Elsevier Science
Year
1974
Tongue
English
Weight
393 KB
Volume
57
Category
Article
ISSN
0006-291X

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Physiologic disposition of 1-(2-chloroet
Physiologic disposition of 1-(2-chloroethyl)-3-cyclohexyl-1-nitrosourea (CCNU) and 1-(2-chloroethyl)-3-(4-methyl cyclohexyl)-1-nitrosourea (MeCCNU) in man
โœ Robert W. Sponzo; Vincent T. Devita; Vincent T. Oliverio ๐Ÿ“‚ Article ๐Ÿ“… 1973 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 466 KB ๐Ÿ‘ 2 views

The physiologic disposition of radioactive-labelled CCNU and MeCCNU was studied in patients receiving these drugs as part of their early clinical trial. CCNU was given orally in doses of 30-100 mg/m2 a n d MeCCNU in doses of 120-290 mg/m?. With both drugs, significant plasma levels of radioactivity