Three cases are reported of Hb S/Hb Lepore combination with very mild sickling manifestations. The presence of a non␣-chain variant with a high proportion of ␦ chain sequences, including 22 ala, appears to ameliorate sickle-cell disease. Efforts to increase the proportion of Hb A 2 may be beneficial
✦ LIBER ✦
Hemoglobin S Antilles: A Variant with Lower Solubility Than Hemoglobin S and Producing Sickle Cell Disease in Heterozygotes
✍ Scribed by Nicole Monplaisir, Guy Merault, Claude Poyart, Marie-Dominique Rhoda, Constantin Craescu, Michel Vidaud, Frédéric Galacteros, Yves Blouquit and Jean Rosa
- Book ID
- 123633622
- Publisher
- National Academy of Sciences
- Year
- 1986
- Tongue
- English
- Weight
- 776 KB
- Volume
- 83
- Category
- Article
- ISSN
- 0027-8424
- DOI
- 10.2307/28621
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