✦ LIBER ✦

Hb S/Hb Lepore with mild sickling symptoms: A hemoglobin variant with mostly δ-chain sequences ameliorates sickle-cell disease

✍ Scribed by Fairbanks, V.F.; McCormick, D.J.; Kubik, K.S.; Rezuke, W.N.; Black, D.; Ochaney, M.S.; Schwartz, D.

Book ID: 101214322
Publisher: John Wiley and Sons
Year: 1997
Tongue: English
Weight: 24 KB
Volume: 54
Category: Article
ISSN: 0361-8609
DOI: 10.1002/(sici)1096-8652(199702)54:2<164::aid-ajh12>3.0.co;2-f

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✦ Synopsis

Three cases are reported of Hb S/Hb Lepore combination with very mild sickling manifestations. The presence of a non␣-chain variant with a high proportion of ␦ chain sequences, including 22 ala, appears to ameliorate sickle-cell disease. Efforts to increase the proportion of Hb A 2 may be beneficial in sickle-cell disease. Am.