Hematoporphyrin derivative for detection and treatment of cancer
โ Scribed by T. J. Dougherty
- Book ID
- 102434721
- Publisher
- John Wiley and Sons
- Year
- 1980
- Tongue
- English
- Weight
- 146 KB
- Volume
- 15
- Category
- Article
- ISSN
- 0022-4790
No coin nor oath required. For personal study only.
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Tbc blue-sbilicd emission from aged ~~IICOUS SO~II~~OIIS of hcmatoporphyrin and its derivatives. reporred by others to origimtc from special~ggrcg.!tcs, isshown to originate from the zinc chelates of the porphyrins. Sagestions arc made regxding the role of such zmc porphyrins in the localization of
This study documents the affinity of hematoporphyrin derivative (HpD) for human colorectal cancer by analysis of surface fluorescence. Ten patients undergoing elective surgery for primary colorectal cancer received intravenous HpD (2-5 mg/kg) either 3 or 72 hours preoperatively. Fluorescent photogra
Photoradiation therapy (PRT) with administration of hematoporphyrin derivative (HPD) was performed in ten cases of early stage central-type lung cancer of which six cases were treated by PRT alone due to inoperability because of poor pulmonary function in five and refusal of surgery in one. Four cas
Tissue culture cells were treated with hematoporphyrin derivative (HPD) and analyzed for (1) H P D uptake, (2) H P D washout, and (3) fluorescence changes. The absorption peaks were the same for H P D in solution and HPD bound to cells. HPD was taken up by all cell types rapidly within the first 10