## Abstract The synthesis of 4‐ and 6‐substituted 1‐H‐ and 1‐phenyl‐pyrazolo‐(3,4‐d)‐pyrimidines is described. It starts from ethyl ethoxymethylene cyanoacetate from which the 4‐hydroxy‐pyrazolo‐(3,4‐d)‐ pyrimidines can be obtained in two steps through the corresponding 2‐substituted 3‐amino‐4‐carb
Heilmittelchemische Studien in der heterocyclischen Reihe. 25. Mitteilung. Pyrazolo-pyrimidine III Paraxanthin-, Theobromin- und Theophyllin-Analoga der Pyrazolo[3,4-d]pyrimidin-Reihe
✍ Scribed by P. Schmidt; K. Eichenberger; J. Dreuey
- Publisher
- John Wiley and Sons
- Year
- 1959
- Tongue
- German
- Weight
- 676 KB
- Volume
- 42
- Category
- Article
- ISSN
- 0018-019X
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✦ Synopsis
Abstract
The preparation of the paraxanthine, theobromine and theophylline isomers 1,5‐; 2,5‐ and 1,7‐; 2,7‐ and 5,7‐dimethyl‐4,6‐dioxo‐4,5,6,7‐tetrahydro‐pyrazolo[3,4‐d]‐pyrimidines is described and their structure established. A structurally specific synthesis of the caffeine and isocaffeine isomers 1,5,7‐ and 2,5,7‐trimethyl‐4,6‐ dioxo‐4,5,6,7‐tetrahydro‐pyrazolo [3,4‐d]pyrimidines has been realized.
📜 SIMILAR VOLUMES
1. Two mechanisms can be admitted for the reactivation of the succinatecytochrome-c reductase system. An earlier described reactivation of the extracted system by isoprene-like substances (vitamins E and K) is to be distinguished from an unspecific reactivation by Z-methyl-l,4-naphthoquinone, which
## Abstract Condensation of 3‐amino‐4‐carbethoxy‐pyrazoles with nitriles led to a new synthesis of 6‐C‐substituted pyrazolo[3,4‐d]pyrimidines and 6‐amino‐pyrazolo‐[3,4‐b]pyridines. The structure of the new derivatives was established by independent syntheses. The pyrazolo‐pyrimidines can be cleaved