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Heilmittelchemische Studien in der heterocyclischen Reihe. 22. Mitteilung. Pyrazolo-pyrimidine II. Pyrazolo[3,4-d]pyrimidine mit Koffein-ähnlicher Struktur und Wirkung

✍ Scribed by P. Schmidt; K. Eichenberger; J. Druey

Publisher
John Wiley and Sons
Year
1958
Tongue
German
Weight
554 KB
Volume
41
Category
Article
ISSN
0018-019X

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✦ Synopsis

  1. Two mechanisms can be admitted for the reactivation of the succinatecytochrome-c reductase system. An earlier described reactivation of the extracted system by isoprene-like substances (vitamins E and K) is to be distinguished from an unspecific reactivation by Z-methyl-l,4-naphthoquinone, which is caused by the redox system.

  2. Ubiquinone, described by Morton, does not reactivate by its redox system but probably by its isoprene like-side chain.

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## Abstract Condensation of 3‐amino‐4‐carbethoxy‐pyrazoles with nitriles led to a new synthesis of 6‐C‐substituted pyrazolo[3,4‐d]pyrimidines and 6‐amino‐pyrazolo‐[3,4‐b]pyridines. The structure of the new derivatives was established by independent syntheses. The pyrazolo‐pyrimidines can be cleaved