✦ LIBER ✦
Heilmittelchemische Studien in der heterocyclischen Reihe. 34. Mitteilung. Pyrazolo-pyrimidine V. Eine neue Synthese von Pyrazolo[3,4-d]pyrimidinen mit coronarerweiternden Eigenschaften
✍ Scribed by P. Schmidt; K. Eichenberger; M. Wilhelm
- Publisher
- John Wiley and Sons
- Year
- 1962
- Tongue
- German
- Weight
- 483 KB
- Volume
- 45
- Category
- Article
- ISSN
- 0018-019X
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✦ Synopsis
Abstract
Condensation of 3‐amino‐4‐carbethoxy‐pyrazoles with nitriles led to a new synthesis of 6‐C‐substituted pyrazolo[3,4‐d]pyrimidines and 6‐amino‐pyrazolo‐[3,4‐b]pyridines. The structure of the new derivatives was established by independent syntheses. The pyrazolo‐pyrimidines can be cleaved with phosphoric acid to 3‐amino‐pyrazole‐4‐carboxamide derivatives. Many of the new pyrazolo‐pyrimidines show an increase of coronary flow.