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Growth charts for young children with neurofibromatosis 1 (NF1)

✍ Scribed by Szudek, Jacek ;Birch, Patricia ;Friedman, Jan M.

Publisher
John Wiley and Sons
Year
2000
Tongue
English
Weight
54 KB
Volume
92
Category
Article
ISSN
0148-7299

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✦ Synopsis

Short stature and macrocephaly are more common in children with neurofibromatosis 1 (NF1) than in the general population. The cause of these growth alterations is unknown in most cases, but monitoring growth in affected children assists in detection of complications such as optic glioma and hydrocephalus. Clementi et al. [1999] developed growth charts for NF1 patients 2 to 18 years old. We have made similar charts from cross-sectional data obtained from the National NF Foundation International Database (NFDB). These are available from http://mendel.medgen.ubc.ca/ friedmanlab. We also developed standard growth charts for total body length (TBL), weight, and occipitofrontal head circumference (OFC) in NF1 patients between 3 and 36 months old.

TBL, weight, and OFC measurements of 336 Caucasian NF1 patients between 3 and 36 months old were obtained from 19 centers contributing data to the NFDB [Friedman et al., 1993]. Patients with clinical findings that could affect measurements were excluded. Analysis of variance was used to determine if significant differences exist among age-and sexstandardized measurements from major contributing centers.

Standard population norms were obtained from studies by the National Center for Health Statistics and the Fels Institute [Hamill et al., 1977;Najjar and Rowland, 1987]. NF1 patients were divided into sex and age groups whose medians correspond to those of the charts for population norms. Centiles were plotted and smoothed using SAS (SAS Institute, Cary, NC, 1996) by producing a cubic spline that minimizes a linear combination of the sum of squares of the residuals of fit and the integral of the square of the second derivative [Reinsch, 1967]. TBL, weight, and OFC centiles by age are shown in

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Reply to the letter to the editor by Szu
Reply to the letter to the editor by Szudek et al.??Growth charts for young children with neurofibromatosis 1 (NF1)?
✍ Clementi, Maurizio; Tenconi, Romano πŸ“‚ Article πŸ“… 2000 πŸ› John Wiley and Sons 🌐 English βš– 729 B πŸ‘ 1 views

The study from Szudek and colleagues provides further data on the growth in children with neurofibromatosis type 1 (NF1). Their sample is lightly biased as they underline that the patients included in the FDB are likely to be more severely affected than NF1 patients in general. However, their data