Neurofibromatosis 1 (NF1) heterozygosity results in a cell-autonomous growth advantage for astrocytes

Tissue-specific differences in the propo

Tissue-specific differences in the proportion of mosaic large NF1 deletions are suggestive of a selective growth advantage of hematopoietic del(+/−) stem cells

✍ Angelika C. Roehl; Tanja Mussotter; David N. Cooper; Lan Kluwe; Katharina Wimmer 📂 Article 📅 2012 🏛 John Wiley and Sons 🌐 English ⚖ 331 KB 👁 1 views

Type-2 NF1 deletions spanning 1.2 Mb are frequently of postzygotic origin and hence tend to be associated with mosaicism for normal cells and those harboring the deletion (del(+/-) cells). Eleven patients with mosaic type-2 deletions were investigated by FISH and high proportions (94-99%) of del(+/-