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Graft copolymers of poly(ethylene glycol) (PEG) and chitosan

✍ Scribed by Hiroshi Saito; Xiangdong Wu; J. Milton Harris; Allan S. Hoffman

Publisher
John Wiley and Sons
Year
1997
Tongue
English
Weight
221 KB
Volume
18
Category
Article
ISSN
1022-1336

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✦ Synopsis

Abstract

Graft copolymers of poly(ethylene glycol) (PEG) on a chitosan backbone (PEG‐g‐chitosan) have been synthesized and their aqueous solution properties were investigated. At pH 6.5 the graft copolymers are 100% soluble, while chitosan phase separates from solution at those conditions. These interesting graft copolymers may be especially suitable as carriers for delivery of anionic drugs, such as proteins, glycosaminoglycans, and DNA plasmids or oligonucleotides.

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