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Regioselective Grafting of Poly(ethylene glycol) onto Chitosan and the Properties of the Resulting Copolymers

✍ Scribed by Li Liu; Fangzhi Li; Yue'e Fang; Shengrong Guo

Publisher
John Wiley and Sons
Year
2006
Tongue
English
Weight
232 KB
Volume
6
Category
Article
ISSN
1616-5187

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✦ Synopsis

Abstract

Summary: PEG was grafted onto chitosan regioselectively at the hydroxyl groups with phthaloylchitosan as an intermediate. After the graft reaction, the phthaloyl groups were deprotected to give chitosan‐g‐PEG copolymers with free amino groups. The chemical structure of the graft copolymers was confirmed by FT‐IR, ^1^H and ^13^C NMR spectroscopy. The resulting graft copolymers showed improved thermal stability compared to the original chitosan, and showed a lower thermal transition temperature at around 185 °C. Chitosan‐g‐PEG exhibited a high affinity not only for aqueous acid but also for some organic solvents because of the presence of abundant free amino groups and PEG branches, and it exhibited higher hygroscopicity and moisture retention ability than chitosan.
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