Preparation of Clickable Poly(3-hydroxyalkanoate) (PHA): Application to Poly(ethylene glycol) (PEG) Graft Copolymers Synthesis

✍ Scribed by Julien Babinot; Estelle Renard; Valérie Langlois

• Publisher: John Wiley and Sons
• Year: 2010
• Tongue: English
• Weight: 240 KB
• Volume: 31
• Category: Article
• ISSN: 1022-1336
• DOI: 10.1002/marc.200900803

✦ Synopsis

Abstract

A new synthesis of amphiphilic biodegradable copolymers consisting of hydrophobic poly(3‐hydroxyalkanoate) (PHA) backbone and hydrophilic poly(ethylene glycol) (PEG) units as side chains is described. Poly[(3‐hydroxyoctanoate)‐co‐(3‐hydroxyundecenoate)] (PHOU) was first methanolyzed and its unsaturated side chains were quantitatively oxidized to carboxylic acid. Esterification with propargyl alcohol led to an alkyne‐containing “clickable” PHA in 71% conversion. Its reactivity was successfully demonstrated by grafting azide‐terminated PEG chains of 550 and 5 000 g · mol^−1^, respectively. All products were fully characterized using GPC, ^1^H, and COSY NMR.

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