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Gold(I)-catalyzed asymmetric aldol reactions of isocyanoacetic acid derivatives with fluoroaryl aldehydes

โœ Scribed by Vadim A. Soloshonok; Alexey D. Kacharov; Tamio Hayashi


Book ID
107857697
Publisher
Elsevier Science
Year
1996
Tongue
French
Weight
742 KB
Volume
52
Category
Article
ISSN
0040-4020

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summsry: Asymmetric aldol reaction of a-ketoesters (RCOCCCMe: R = Me, i-Bu, ph) with methyl isocyanoacetate or N,N-dimethyl-a-isocyanoacetamide in the presence of 1 molX of a chiral (arinoalkyl)ferrocenylphosphine-gold(I) catalyst proceeded with high enantioselectivity to give corresponding oxazolin