Gold(I)-catalyzed asymmetric aldol reactions of isocyanoacetic acid derivatives with fluoroaryl aldehydes
โ Scribed by Vadim A. Soloshonok; Alexey D. Kacharov; Tamio Hayashi
- Book ID
- 107857697
- Publisher
- Elsevier Science
- Year
- 1996
- Tongue
- French
- Weight
- 742 KB
- Volume
- 52
- Category
- Article
- ISSN
- 0040-4020
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๐ SIMILAR VOLUMES
A ferrocenylphosphine-silver-isocyanoacetate complex was investigated as a model compound for catalytic species in gold-catalyzed aldol reaction. 'H{lH} NOE studies of the silver complex indicated that terminal amino group of pendant side chain of the ferrocenylphosphine ligand is located close to a
summsry: Asymmetric aldol reaction of a-ketoesters (RCOCCCMe: R = Me, i-Bu, ph) with methyl isocyanoacetate or N,N-dimethyl-a-isocyanoacetamide in the presence of 1 molX of a chiral (arinoalkyl)ferrocenylphosphine-gold(I) catalyst proceeded with high enantioselectivity to give corresponding oxazolin