Asymmetric aldol reaction of methyl a-lsoryanoacetate with (&2-hexadecenal In the presence of 1 mol% of a choral (amlnoalkyl)ferrocenylphosphlne-gold(I) romplex gave optirally active trans-4-(methoxycarbonyl)-5-((E)-l-pentade~enyl)-2-oxazollne (93% ee) which was readily converted into Q-threo-and er
Erythro-Selective aldol-type reaction of N-sulfonylaldimines with methyl isocyanoacetate catalyzed by gold(I)
โ Scribed by Tamio Hayashi; Eiji Kishi; Vadim A. Soloshonok; Yasuhiro Uozumi
- Publisher
- Elsevier Science
- Year
- 1996
- Tongue
- French
- Weight
- 240 KB
- Volume
- 37
- Category
- Article
- ISSN
- 0040-4039
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๐ SIMILAR VOLUMES
During last two decades, a growing number of papers dealing with fluorine-containing amino acids have demonstrated the usefulness of these amino acids in the design of novel biologically active compounds as well as in the study of the biological chemistry. 2 A large number of fluoroamino acids have
summsry: Asymmetric aldol reaction of a-ketoesters (RCOCCCMe: R = Me, i-Bu, ph) with methyl isocyanoacetate or N,N-dimethyl-a-isocyanoacetamide in the presence of 1 molX of a chiral (arinoalkyl)ferrocenylphosphine-gold(I) catalyst proceeded with high enantioselectivity to give corresponding oxazolin