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Silver(I)-catalyzed asymmetric aldol reaction of isocyanoacetate

โœ Scribed by Tamio Hayashi; Yasuhiro Uozumi; Akiko Yamazaki; Masaya Sawamura; Hitoshi Hamashima; Yoshihiko Ito


Book ID
103403797
Publisher
Elsevier Science
Year
1991
Tongue
French
Weight
276 KB
Volume
32
Category
Article
ISSN
0040-4039

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A ferrocenylphosphine-silver-isocyanoacetate complex was investigated as a model compound for catalytic species in gold-catalyzed aldol reaction. 'H{lH} NOE studies of the silver complex indicated that terminal amino group of pendant side chain of the ferrocenylphosphine ligand is located close to a

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summsry: Asymmetric aldol reaction of a-ketoesters (RCOCCCMe: R = Me, i-Bu, ph) with methyl isocyanoacetate or N,N-dimethyl-a-isocyanoacetamide in the presence of 1 molX of a chiral (arinoalkyl)ferrocenylphosphine-gold(I) catalyst proceeded with high enantioselectivity to give corresponding oxazolin