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GlutathioneS-transferase M1 and T1 null genotype distribution in South Indians

✍ Scribed by A. T. Naveen; C. Adithan; N. Padmaja; C. H. Shashindran; B. K. Abraham; K. Satyanarayanamoorthy; P. Anitha; N. Gerard; R. Krishnamoorthy

Publisher
Springer
Year
2004
Tongue
English
Weight
158 KB
Volume
60
Category
Article
ISSN
0031-6970

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Glutathione S-transferase M1 and T1 null
Glutathione S-transferase M1 and T1 null genotypes increase susceptibility to drug-induced liver injury
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We appreciate the comments of Leiro et al. on the role of the combined glutathione-S-transferase M1 (GSTM1) and glutathione-S-transferase T1 (GSTT1) null genotypes in determining the susceptibility to developing idiosyncratic drug-induced liver injury (DILI) as a general mechanism that occurs regard

Glutathione S-transferase m1 and t1 null
Glutathione S-transferase m1 and t1 null genotypes increase susceptibility to idiosyncratic drug-induced liver injury
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on behalf of the Spanish Group for the Study of Drug-Induced Liver Disease Individual vulnerability to drug-induced liver injury (DILI) might result from deficiencies in the detoxification process, which determines the level of exposure to the reactive metabolite. We evaluated whether a genetically