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Glutathione transferase T1 and M1 genotype polymorphism in the normal population of Shanghai

✍ Scribed by Jianhua Shen; Goufang Lin; Wuxing Yuan; Jingwei Tan; Hermann M. Bolt; Ricarda Thier


Publisher
Springer-Verlag
Year
1998
Tongue
English
Weight
192 KB
Volume
72
Category
Article
ISSN
0340-5761

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Gene codings for glutathione S-transferase T1 (GSTT1) and M1 (GSTM1) are polymorphic in humans with null genotypes present in approximately 20 and 50%, respectively. A significant excess of homozygous null GSTT1 and GSTM1 genotypes has been demonstrated among individuals with certain types of cancer

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## Abstract Isothiocyanates (ITC) in cruciferous vegetables may be chemopreventive against gastric cancer development. Glutathione __S__‐transferases (GSTs) may modify the chemopreventive effect of ITC. The relationship between urinary total ITC and risk of gastric cancer was prospectively examined