Glutathione transferase T1 and M1 genotype polymorphism in the normal population of Shanghai
β Scribed by Jianhua Shen; Goufang Lin; Wuxing Yuan; Jingwei Tan; Hermann M. Bolt; Ricarda Thier
- Publisher
- Springer-Verlag
- Year
- 1998
- Tongue
- English
- Weight
- 192 KB
- Volume
- 72
- Category
- Article
- ISSN
- 0340-5761
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π SIMILAR VOLUMES
Gene codings for glutathione S-transferase T1 (GSTT1) and M1 (GSTM1) are polymorphic in humans with null genotypes present in approximately 20 and 50%, respectively. A significant excess of homozygous null GSTT1 and GSTM1 genotypes has been demonstrated among individuals with certain types of cancer
## Abstract Isothiocyanates (ITC) in cruciferous vegetables may be chemopreventive against gastric cancer development. Glutathione __S__βtransferases (GSTs) may modify the chemopreventive effect of ITC. The relationship between urinary total ITC and risk of gastric cancer was prospectively examined