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Glutathione S-transferase M1 and T1 null genotypes increase susceptibility to drug-induced liver injury

✍ Scribed by Virginia Leiro Fernández; Alberto Fernández-Villar; Rafael Vázquez Gallardo; Diana Valverde Pérez

Publisher: John Wiley and Sons
Year: 2009
Tongue: English
Weight: 45 KB
Volume: 49
Category: Article
ISSN: 0270-9139
DOI: 10.1002/hep.22910

No coin nor oath required. For personal study only.

✦ Synopsis

We appreciate the comments of Leiro et al. on the role of the combined glutathione-S-transferase M1 (GSTM1) and glutathione-S-transferase T1 (GSTT1) null genotypes in determining the susceptibility to developing idiosyncratic drug-induced liver injury (DILI) as a general mechanism that occurs regardless of the type of drug involved. 1 These enzymes are predominantly expressed in the liver, and apart from being involved in drug metabolism, they modulate the byproducts of oxidative stress, an important common

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