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Glutathione depletion upregulates P-glycoprotein expression at the blood-brain barrier in rats

✍ Scribed by Jing Wu; Hao Hong; Hui Ji; Ying Yu Wang; Ying Wang; Yong Qi Li; Wei Guang Li; Yan Long; Yuan Zheng Xia


Book ID
111770964
Publisher
Pharmaceutical Press
Year
2009
Tongue
English
Weight
214 KB
Volume
61
Category
Article
ISSN
2042-7158

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This article describes the experimental set-up and pharmacokinetic modeling of P-glycoprotein function in the rat blood-brain barrier using [ 11 C]verapamil as the substrate and cyclosporin A as an inhibitor of P-gp. [ 11 C]verapamil was administered to rats as an i.v. bolus dose followed by graded