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Minocycline and riluzole brain disposition: interactions with p-glycoprotein at the blood–brain barrier

✍ Scribed by Aline Milane; Christine Fernandez; Sarah Vautier; Gilbert Bensimon; Vincent Meininger; Robert Farinotti


Book ID
111180326
Publisher
John Wiley and Sons
Year
2007
Tongue
English
Weight
272 KB
Volume
0
Category
Article
ISSN
0022-3042

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This article describes the experimental set-up and pharmacokinetic modeling of P-glycoprotein function in the rat blood-brain barrier using [ 11 C]verapamil as the substrate and cyclosporin A as an inhibitor of P-gp. [ 11 C]verapamil was administered to rats as an i.v. bolus dose followed by graded